(WEB PAGE PDF)
All the changes that have been made to the monograph since initial posting are listed below in reverse chronological order.
→ None of the following corrections affect the content of the manuscript. ←
Errata
| Date | Section | Description |
| 2026 Jan 21 | Downloadable PDF files |
The downloadable PDF files of this picornavirus monograph
have been updated with the corrections dated “2026 Jan 21”.
These corrections are listed below.
The page header of these updated PDF files shows “26 Nov. 2016 r2” as a designation for “revision 2”.
The older versions of the picornavirus monograph may still be downloaded for reference: (Initial Monograph 6 MB PDF) (Initial Monograph 12 MB PDF) (Revision 1 Monograph 3 MB PDF) (Revision 1 Monograph 6 MB PDF) (Revision 1 Monograph 12 MB PDF) (Revision 1 Monograph 24 MB PDF) |
| 2026 Jan 21 | Introduction | In the Introduction, instances of "plecornaril" were changed to "pleconaril". The line: The INSERT LOOP of EV-D68-4WM7 has flanking residues missing from the crystal structure has critical residues (e.g., H87) different from other pathogenic EV-D68 sequences (e.g., D87), and presents groups in close contact with bound plecornaril (e.g., L220). was replaced by the following line: The INSERT LOOP of EV-D68-4WM7 has flanking residues missing from the crystal structure has critical residues (e.g., H87) different from other pathogenic EV-D68 sequences (e.g., D87), and presents groups in close contact with bound pleconaril (e.g., L220). The line: Despite the difference in sequence between the EV-D68-4WM7 VP1 proteins and pathogenic EV-D68 proteins, and despite the absence of flanking residues in the EV-D68-4WM7 INSERT LOOP, the constructed capsid allowed us to isolate the position of pathogenic EV-D68-4WM7 INSERT LOOP residues, compare the EV-D68-4WM7 INSERT LOOP residues to PV1, and relate the EV-D68 TOX DOMAIN residues to the positions of bound plecornaril. was replaced by the following line: Despite the difference in sequence between the EV-D68-4WM7 VP1 proteins and pathogenic EV-D68 proteins, and despite the absence of flanking residues in the EV-D68-4WM7 INSERT LOOP, the constructed capsid allowed us to isolate the position of pathogenic EV-D68-4WM7 INSERT LOOP residues, compare the EV-D68-4WM7 INSERT LOOP residues to PV1, and relate the EV-D68 TOX DOMAIN residues to the positions of bound pleconaril. The line: We hypothesize that mutations in EV-D68 or EV-D70 will be seen in residues at positions that either contact plecornaril (or similar molecules) and/or will be seen in residues that contact or impact TOX DOMAIN residues. was replaced by the following line: We hypothesize that mutations in EV-D68 or EV-D70 will be seen in residues at positions that either contact pleconaril (or similar molecules) and/or will be seen in residues that contact or impact TOX DOMAIN residues. |
| 2026 Jan 21 | Spatially Reconstituted Toxin Loops And The Paralysis Associated Domain | In Results Section “Spatially Reconstituted Toxin Loops And The Paralysis Associated Domain”, instances of "plecornaril" were changed to "pleconaril". The line: TOXLOOP1 in the EV-D68 ET AL. TOX DOMAIN may act to enhance the binding of the EV-D68 capsid to acetylcholine receptors and/or the binding of plecornaril to EV-D68. was replaced by the following line: TOXLOOP1 in the EV-D68 ET AL. TOX DOMAIN may act to enhance the binding of the EV-D68 capsid to acetylcholine receptors and/or the binding of pleconaril to EV-D68. The line: Figure 10 panels G — J show plecornaril, a proposed antiviral, as white spheres. was replaced by the following line: Figure 10 panels G — J show pleconaril, a proposed antiviral, as white spheres. The line: Given the endpoints of the missing residues N212-P213-A214-D215, it is clear that the N212-P213-A214-D215 residues are adjacent to the bound plecornaril, may contact the bound plecornaril, and may impact the binding of plecornaril. was replaced by the following line: Given the endpoints of the missing residues N212-P213-A214-D215, it is clear that the N212-P213-A214-D215 residues are adjacent to the bound pleconaril, may contact the bound pleconaril, and may impact the binding of pleconaril. The line: An examination of Figure 10 panels K and L show the location of the residues flanking the missing G129-N130-N131-D132-S133-T134 (Figure 1 Section M-7) in relationship to the residues flanking the missing S81-S82-S83-A84-G85, the residues flanking the missing N212-P213-A214-D215, and the bound plecornaril (i.e., in a single 3xVP1234). was replaced by the following line: An examination of Figure 10 panels K and L show the location of the residues flanking the missing G129-N130-N131-D132-S133-T134 (Figure 1 Section M-7) in relationship to the residues flanking the missing S81-S82-S83-A84-G85, the residues flanking the missing N212-P213-A214-D215, and the bound pleconaril (i.e., in a single 3xVP1234). |
| 2026 Jan 21 | Figure 10 | In Figure 10 Description, instances of "plecornaril" were changed to "pleconaril". The line: Plecornaril spheres and sticks are colored white. was replaced by the following line: Pleconaril spheres and sticks are colored white. The line: In panels G, H, I , J, K, and L, plecornaril is represented by white spheres or sticks. was replaced by the following line: In panels G, H, I , J, K, and L, pleconaril is represented by white spheres or sticks. |
| 2022 July 7 | Downloadable PDF files |
The downloadable PDF files of this picornavirus monograph
have been updated with the corrections dated “2018 Aug 30”.
These corrections are listed below.
The page header of these updated PDF files shows “26 Nov. 2016 r1” as a designation for “revision 1”.
The older (initial) picornavirus monograph may still be downloaded for reference: (Initial Monograph 6 MB PDF) (Initial Monograph 12 MB PDF) |
| 2018 Aug 30 | Errata Link | Errata page added concurrent with the first corrections made to original monograph. |
| 2018 Aug 30 | Authors | “Weininger Works Incorporated, Thornhill, Ontario, Canada” was removed from both authors. |
| 2018 Aug 30 | Supporting Information | Supporting Information file ICOS135.pdb altered to have appropriate formatting. Supporting Information, ICOS135.pdb had a CONECT record split into two CONECT records to conform to wwPDB standard. The CONECT record had five bonded atoms for HETATM 1; only four bonded atoms are allowed per CONECT line per the official wwpdb standard. The line: CONECT 1 2 3 4 5 6 was replaced by the following two lines: CONECT 1 2 3 4 5 CONECT 1 6 |
| 2018 Aug 30 | Sialic Acid Binding Domain in EV-D68 | In Results Section “Sialic Acid Binding Domain in EV-D68”, a residue was changed to match the used and cited residue. The line: The common sialic acid active site residues in the N6 neuraminidase [12] are: Y412 (tan), D157 (red), R124 (cyan), E227 (red), R158 (cyan), R 299 (cyan), and W185 (orange). was replaced by the following line: The common sialic acid active site residues in the N6 neuraminidase [12] are: Y412 (tan), D157 (red), R124 (cyan), G227 (red), R158 (cyan), R 299 (cyan), and W185 (orange). |
| 2018 Aug 30 | Sialic Acid Binding Domain in EV-D68 | In Results Section “Sialic Acid Binding Domain in EV-D68”, Figure 1 location references were changed to match used and labelled figure 1 locations. The line: The Figure 1 sections containing putative sialic acid binding site residues are marked with subsection title suffix “-SW” in the Figure 1 row labelled “SUBSECTION DESCRIPTOR MARKER” (i.e., E75 (red, Figure 1 Section I13-1), Y76 (yellow, Figure 1 Section I13-1), D140 (red, Figure 1 Section M-8), W163 (orange, Figure 1 Section M-12), R223 (blue, Figure 1 Section I1-5), E227 (red, Figure 1 Section M-13), R270 and R284 (blue, Figure 1 Section M-16)). was replaced by the following line: The Figure 1 sections containing putative sialic acid binding site residues are marked with subsection title suffix “-SW” in the Figure 1 row labelled “SUBSECTION DESCRIPTOR MARKER” (i.e., E75 (red, Figure 1 Section I13-1), Y76 (yellow, Figure 1 Section I13-1), D140 (red, Figure 1 Section M-8), W163 (orange, Figure 1 Section M-12), R223 (blue, Figure 1 Section A-2), E227 (red, Figure 1 Section M-13), R270 (blue, Figure 1 Section I1-5), and R284 (blue, Figure 1 Section M-16)). |
| 2018 Aug 30 | Figure 4 | Figure 4 Panel H6 had missing panel label 'H6' added. |
| 2018 Aug 30 | Figure 7 | In Figure 7 Panel B Description, an 's' was added for a plural (grammar). The line: …a complete set of nine destination point for… was replaced by the following line: …a complete set of nine destination points for… |
| 2018 Aug 30 | Figure 11 | In Figure 11 Description, a residue was changed to match the used and cited residue. The line: Figure 11 Panel A shows the influenza N6 neuraminidase [49] cartoon and residue spheres of: Y412 (tan), D157 (red), R124 (cyan), E227 (red), R158 (cyan), R 299 (cyan), and W185 (orange). was replaced by the following line: Figure 11 Panel A shows the influenza N6 neuraminidase [49] cartoon and residue spheres of: Y412 (tan), D157 (red), R124 (cyan), G227 (red), R158 (cyan), R 299 (cyan), and W185 (orange). |
| 2018 Aug 30 | Figure 11 | In Figure 11 Description, panel reference was changed to match figure. The line: Panel D adds green residue spheres of sialic acid to Panel A. was replaced by the following line: Panel B adds green residue spheres of sialic acid to Panel A. |
| 2018 Aug 30 | Figure 11 | In Figure 11 Description, Figure 1 location references were changed to match used and labelled figure 1 locations. Also an extra comma was removed. The line: Figure 11 Panel C shows a cartoon of EV-D68 VP1 and spheres for residues that we have identified in the Figure 1 row labelled “SUBSECTION DESCRIPTOR MARKER” with the subsection title suffix “-SW” (i.e., E75 (red, Figure 1 Section I13-1), Y76 (yellow,,Figure 1 Section I13-1), D140 (red, Figure 1 Section M-8), W163 (orange, Figure 1 Section M-12), R223 (blue, Figure 1 Section I1-5), E227 (red, Figure 1 Section M-13), R270 and R284 (blue, Figure 1 Section M-16) residues). was replaced by the following line: Figure 11 Panel C shows a cartoon of EV-D68 VP1 and spheres for residues that we have identified in the Figure 1 row labelled “SUBSECTION DESCRIPTOR MARKER” with the subsection title suffix “-SW” (i.e., E75 (red, Figure 1 Section I13-1), Y76 (yellow, Figure 1 Section I13-1), D140 (red, Figure 1 Section M-8), W163 (orange, Figure 1 Section M-12), R223 (blue, Figure 1 Section A-2), E227 (red, Figure 1 Section M-13), R270 (blue, Figure 1 Section I1-5), and R284 (blue, Figure 1 Section M-16) residues). |
| 2018 Aug 30 | Figure 12 | In Figure 12 Panel H Description, residue was changed to match the used and cited TMEV structure TMEV-2 (1TMF.pdb). The line: Panel H shows TMEV-2 VP3 protein spheres (tan) with dark brown N58-S59-N60-N61-K62-R63-Y64 residue marker spheres. was replaced by the following line: Panel H shows TMEV-2 VP3 protein spheres (tan) with dark brown N58-T59-N60-N61-K62-R63-Y64 residue marker spheres. |
| 2018 Aug 30 | Figure 12 | In Figure 12 Panel L Description, panel reference was changed to match figure. The line: Panel L shows the superposition of Panels J and L. was replaced by the following line: Panel L shows the superposition of Panels J and K. |
| 2018 Aug 30 | Figure 12 | In Figure 12 Panel P Description, protein reference was changed to match the used and labelled figure. The line: Panel P shows TMEV-1 3xVP1234 pentamer VP1 structure cartoons (in yellow) and the TMEV-1 marker spheres. was replaced by the following line: Panel P shows TMEV-1 3xVP1234 pentamer VP3 structure cartoons (in yellow) and the TMEV-1 marker spheres. |
| 2018 Aug 30 | Figure 12 | In Figure 12 Panel Q Description, protein reference was changed to match the used and labelled figure. The line: Panel Q shows TMEV-2 3xVP1234 pentamer VP1 structure cartoons (in tan) and the TMEV-2 marker spheres. was replaced by the following line: Panel Q shows TMEV-2 3xVP1234 pentamer VP3 structure cartoons (in tan) and the TMEV-2 marker spheres. |